Chromosome Cohesion Decreases in Human Eggs with Advanced Maternal Age.
نویسندگان
چکیده
منابع مشابه
advanced maternal age relationship with pregnancy complications
background: due to increase in pregnancy complications in advanced age, this study was conducted to assess the relationship between advanced maternal age and the pregnancy complications. methods: pregnant women who admitted to the motazedi hospital in kermanshah were included in this analytic–cross sectional study. the study group was 1178 cases that divided into two sub-groups; 35-40 year-old ...
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BACKGROUND Chromosome segregation errors during human oocyte meiosis are associated with low fertility in humans and the incidence of these errors increases with advancing maternal age. Studies of mitosis and meiosis suggest that defective remodeling of chromatin plays a causative role in aneuploidy. We analyzed the histone deacetylation pattern during the final stages of human oocyte maturatio...
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A retrospective review of medical records of 80 children with thyroid dysgenesis (TD) was conducted to determine the association of gender and maternal age with TD. The study subjects were attending the Pediatric Endocrinology Clinic of our hospital which is a large tertiary care Multispecialty Pediatric Center located in Chandigarh, Northwest India. There were no gender differences (boys to gi...
متن کاملSister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect
Aneuploidy in human eggs is the leading cause of pregnancy loss and Down's syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. Here, we show that many sister kinetochores in human oocytes are separated and do not beha...
متن کاملChromosome Cohesion: Closing Time
Ever since the founding work of Walther Fleming more than a century ago, the process by which one cell divides to create two daughters has fascinated biologists. But only now are we beginning to understand the mechanisms that underlie the coordinated distribution of the duplicated chromosomes — sister chromatids — to the two daughters when a eukaryotic cell divides. At the heart of this process...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2012
ISSN: 0006-3363,1529-7268
DOI: 10.1093/biolreprod/87.s1.60